Adjunct Professor
M_PEDS-ALLERGY IMMUNOLOGY
Dr. Mack's laboratory is focused on understanding the molecular, genetic, functional and evolutionary basis of the immune system, and in particular the highly polymorphic Human Leukocyte Antigen (HLA) genes and Killer-cell Immunoglobulin-like Receptor (KIR) genes. His laboratory develops methods, tools, systems, services and protocols that facilitate clinical and research goals for bone-marrow and stem-cell transplantation therapies, understanding immune-related disease-association, and human health.
In addition. Dr. Mack serves UCSF's ARCHES Program, an initiative focused on supporting and advancing the career development of research faculty, as a Co-Lead on the development of community and scientific networks.
Publications
HLAtools, Searching Shared HLA Amino Acid Residue Prevalence, and the Global Frequency Browsers: New Computational Resources for Working With HLA Data and Visualizing Global Patterns of HLA Variation.
International journal of immunogenetics
Etiologic Determinants and Characteristics of Diabetes in Haitian Youth (EDDHY Study).
Pediatric diabetes
Association between HLA genetics and SARS-CoV-2 infection in a large real-world cohort.
Genes and immunity
Natural Selection on HLA-DPB1 Amino Acids Operates Primarily on DP Serologic Categories.
Human immunology
Population genetic dissection of HLA-DPB1 amino acid polymorphism to infer selection.
Human immunology
Curating Genetic Associations With Rheumatologic Autoimmune Diseases to Improve Patient Outcomes.
Arthritis & rheumatology (Hoboken, N.J.)
Non-invasive prenatal testing of beta-hemoglobinopathies using next generation sequencing, in-silico sequence size selection, and haplotyping.
Croatian medical journal
PyPop: a mature open-source software pipeline for population genomics.
Frontiers in immunology
Clinical features, biochemistry, and HLA-DRB1 status in youth-onset type 1 diabetes in Mali.
Pediatric diabetes
The immunogenetics of viral antigen response is associated with subtype-specific glioma risk and survival.
American journal of human genetics
HLA-DRB1 and -DQB1 Alleles, Haplotypes and Genotypes in Emirati Patients with Type 1 Diabetes Underscores the Benefits of Evaluating Understudied Populations.
Frontiers in genetics
Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research.
Frontiers in genetics
Current HLA Investigations on SARS-CoV-2 and Perspectives.
Frontiers in genetics
Challenges for the standardized reporting of NGS HLA genotyping: Surveying gaps between clinical and research laboratories.
Human immunology
Clinical features, biochemistry, and HLA-DRB1 status in youth-onset type 1 diabetes in Sudan.
Pediatric diabetes
SNP-HLA Reference Consortium (SHLARC): HLA and SNP data sharing for promoting MHC-centric analyses in genomics.
Genetic epidemiology
Preface: 17th International HLA and Immunogenetics Workshop.
Human immunology
Clinical features, biochemistry and HLA-DRB1 status in children and adolescents with diabetes in Dhaka, Bangladesh.
Diabetes research and clinical practice
HLA alleles and haplotypes observed in 263 US families.
Human immunology
Correction: High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.
Genes and immunity
Quality control project of NGS HLA genotyping for the 17th International HLA and Immunogenetics Workshop.
Human immunology
Clinical features, biochemistry and HLA-DRB1 status in youth-onset type 1 diabetes in Pakistan.
Diabetes research and clinical practice
Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 496 adults from San Diego, California, USA.
Human immunology
Epidemiology of childhood-onset type 1 diabetes in Azerbaijan: Incidence, clinical features, biochemistry, and HLA-DRB1 status.
Diabetes research and clinical practice
High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.
Genes and immunity
Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 714 adults from Colombo, Sri Lanka.
Human immunology
Collection and storage of HLA NGS genotyping data for the 17th International HLA and Immunogenetics Workshop.
Human immunology
Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 339 adults from Managua, Nicaragua.
Human immunology
Significant variation between SNP-based HLA imputations in diverse populations: the last mile is the hardest.
The pharmacogenomics journal
Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya.
Human immunology
Update on short population reports.
Human immunology
Bridging ImmunoGenomic Data Analysis Workflow Gaps (BIGDAWG): An integrated case-control analysis pipeline.
Human immunology
The GL service: Web service to exchange GL string encoded HLA & KIR genotypes with complete and accurate allele and genotype ambiguity.
Human immunology
HLA Haplotype Validator for quality assessments of HLA typing.
Human immunology
Histoimmunogenetics Markup Language 1.0: Reporting next generation sequencing-based HLA and KIR genotyping.
Human immunology
Introducing a new manuscript format: Enabling access to immunogenomic population data with short population reports.
Human immunology
HLA-DPB1 and HLA class I confer risk of and protection from narcolepsy.
American journal of human genetics
Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos.
The Journal of allergy and clinical immunology
Human immunology in the era of big data.
Human immunology
Genotype List String: a grammar for describing HLA and KIR genotyping results in a text string.
Tissue antigens
16(th) IHIW: immunogenomic data-management methods. report from the immunogenomic data analysis working group (IDAWG).
International journal of immunogenetics
16(th) IHIW: extending the number of resources and bioinformatics analysis for the investigation of HLA rare alleles.
International journal of immunogenetics
A sequence-based approach demonstrates that balancing selection in classical human leukocyte antigen (HLA) loci is asymmetric.
Human molecular genetics
Tuberculosis, incarceration, and HIV at a crossroads in Guyana.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Tracking human migrations by the analysis of the distribution of HLA alleles, lineages and haplotypes in closed and open populations.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Analytical methods for disease association studies with immunogenetic data.
Methods in molecular biology (Clifton, N.J.)
Analytical methods for immunogenetic population data.
Methods in molecular biology (Clifton, N.J.)
Standard methods for the management of immunogenetic data.
Methods in molecular biology (Clifton, N.J.)
Tuberculosis and diabetes in Guyana.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
The CWD allele catalog in China.
Human immunology
Sequence feature variant type (SFVT) analysis of the HLA genetic association in juvenile idiopathic arthritis.
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Association analysis of SNPs in the IL4R locus with type I diabetes.
Genes and immunity
HLA-A, -B, -C, and -DRB1 allele and haplotype frequencies distinguish Eastern European Americans from the general European American population.
Tissue antigens
Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies.
Human immunology
Genetic origin of the Swedish Sami inferred from HLA class I and class II allele frequencies.
European journal of human genetics : EJHG
14th International HLA and Immunogenetics Workshop: report of progress in methodology, data collection, and analyses.
Tissue antigens
Population samples and genotyping technology.
Tissue antigens
Common and well-documented HLA alleles: report of the Ad-Hoc committee of the american society for histocompatiblity and immunogenetics.
Human immunology
HLA-A, -B, -C, -DRB1 allele and haplotype frequencies in an African American population.
Tissue antigens
Effect of brushing on fluoride release from 3 bracket adhesives.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics
Association of HLA class I and II alleles and extended haplotypes with nasopharyngeal carcinoma in Taiwan.
Journal of the National Cancer Institute
HLA antigens, alleles and haplotypes among the Yup'ik Alaska natives: report of the ASHI Minority Workshops, Part II.
Human immunology
Genetic variation among the Golla pastoral caste subdivisions of Andhra Pradesh, India, according to the HLA system.
Human immunology
Genetic variability and linkage disequilibrium within the HLA-DP region: analysis of 15 different populations.
Tissue antigens
Evolution of Pacific/Asian populations inferred from HLA class II allele frequency distributions.
Tissue antigens
Hardy-Weinberg testing for HLA class II (DRB1, DQA1, DQB1, and DPB1) loci in 26 human ethnic groups.
Tissue antigens
Tracing the origin of HLA-DRB1 alleles by microsatellite polymorphism.
American journal of human genetics
HLA class I allele distributions in six Pacific/Asian populations: evidence of selection at the HLA-A locus.
Tissue antigens